Society of Regenerative Sciences (India)

(Formerly known as Stem Cell Society (India))

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International Publications On Stroke

Stroke Publications International

  1. Nagpal A, Choy FC, Howell S, Hillier S, Chan F, Hamilton-Bruce MA, Koblar SA. Safety and effectiveness of stem cell therapies in early-phase clinical trials in stroke: a systematic review and meta-analysis. Stem Cell Res Ther. 2017 Aug 30;8(1):191. doi: 10.1186/s13287-017-0643-x. PubMed PmiD: 28854961; PubMed Central PMCID: PMC5577822.
  2. Jaillard A, Hommel M, Moisan A, Zeffiro TA, Favre-Wiki IM, Barbieux-Guillot M, Vadot W, Marcel S, Lamalle L, Grand S, Detante O; (for the ISIS-HERMES Study Group). Autologous Mesenchymal Stem Cells Improve Motor Recovery in Subacute Ischemic Stroke: a Randomized Clinical Trial. Transl Stroke Res. 2020 Oct;11(5):910-923. doi: 10.1007/s12975-020-00787-z. Epub 2020 May 27. PmiD: 32462427.
  3. Suda S, Nito C, Ihara M, Iguchi Y, Urabe T, Matsumaru Y, Sakai N, Kimura K; J- REPAIR trial group. Randomised placebo-controlled multicentre trial to evaluate the efficacy and safety of JTR-161, allogeneic human dental pulp stem cells, in patients with Acute Ischaemic stRoke (J-REPAIR). BMJ Open. 2022 May 24;12(5):e054269. doi: 10.1136/bmjopen-2021-054269. PmiD: 35613802; PMCID: PMC9125710.
  4. de Celis-Ruiz E, Fuentes B, Alonso de Leciñana M, Gutiérrez-Fernández M, Borobia AM, Gutiérrez-Zúñiga R, Ruiz-Ares G, Otero-Ortega L, Laso-García F, Gómez-de Frutos MC, Díez-Tejedor E. Final Results of Allogeneic Adipose Tissue-Derived Mesenchymal Stem Cells in Acute Ischemic Stroke (AMASCIS): A Phase II, Randomized, Double-Blind, Placebo-Controlled, Single-Center, Pilot Clinical Trial. Cell Transplant. 2022 Jan-Dec;31:9636897221083863. doi: 10.1177/09636897221083863. PmiD: 35301883; PMCID: PMC8943307.
  5. Wang K, Rong L, Wei X, Zhang Q, Xiao L. The effectiveness of various cytotherapeutic strategies for the treatment of ischemic stroke: a Bayesian network meta-analysis of randomized controlled trials. Neurol Sci. 2020 Jul;41(7):1705-1717. doi: 10.1007/s10072-020-04312-w. Epub 2020 Mar 4. PmiD: 32130557.
  6. Hess DC, Wechsler LR, Clark WM, Savitz SI, Ford GA, Chiu D, Yavagal DR, Uchino K, Liebeskind DS, Auchus AP, Sen S. Safety and efficacy of multipotent adult progenitor cells in acute ischaemic stroke (MASTERS): a randomised, double-blind, placebo-controlled, phase 2 trial. The Lancet Neurology. 2017 May 1;16(5):360-8.
  7. Moniche F, Escudero I, Zapata-Arriaza E, Usero-Ruiz M, Prieto-León M, de la Torre J, Gamero MA, Tamayo JA, Ochoa-Sepúlveda JJ, Maestre J, Carmona M. Intra-arterial bone marrow mononuclear cells (BM-MNCs) transplantation in acute ischemic stroke (IBIS trial): protocol of a phase II, randomized, dose-finding, controlled multicenter trial. International Journal of Stroke. 2015 Oct;10(7):1149-52.
  8. Bang OY, Lee JS, Lee PH, Lee G. Autologous mesenchymal stem cell transplantation in stroke patients. Ann Neurol. 2005;57(6):874–882. doi: 10.1002/ana.20501.
  9. Savitz SI, Yavagal D, Rappard G, Likosky W, Rutledge N, Graffagnino C, Alderazi Y, Elder JA, Chen PR, Budzik RF Jr, Tarrel R, Huang DY, Hinson JM Jr. A Phase 2 Randomized, Sham-Controlled Trial of Internal Carotid Artery Infusion of Autologous Bone Marrow-Derived ALD-401 Cells in Patients With Recent Stable Ischemic Stroke (RECOVER-Stroke). Circulation. 2019 Jan 8;139(2):192-205. doi: 10.1161/CIRCULATIONAHA.117.030659. PmiD: 30586746.
  10. Deng L, Peng Q, Wang H, Pan J, Zhou Y, Pan K, Li J, Wu Y, Wang Y. Intrathecal Injection of Allogenic Bone Marrow-Derived Mesenchymal Stromal Cells in Treatment of Patients with Severe Ischemic Stroke: Study Protocol for a Randomized Controlled Observer-Blinded Trial. Transl Stroke Res. 2019 Apr;10(2):170-177. doi: 10.1007/s12975-018-0634-y. Epub 2018 May 23. PmiD: 29796934.
  11. Chung JW, Chang WH, Bang OY, Moon GJ, Kim SJ, Kim SK, Lee JS, Sohn SI, Kim YH; STARTING-2 Collaborators. Efficacy and Safety of Intravenous Mesenchymal Stem Cells for Ischemic Stroke. Neurology. 2021 Feb 16;96(7):e1012-e1023. doi: 10.1212/WNL.0000000000011440. Epub 2021 Jan 20. PmiD: 33472925.
  12. Lee J, Chang WH, Chung JW, Kim SJ, Kim SK, Lee JS, Sohn SI, Kim YH, Bang OY; STARTING-2 Collaborators. Efficacy of Intravenous Mesenchymal Stem Cells for Motor Recovery After Ischemic Stroke: A Neuroimaging Study. Stroke. 2022 Jan;53(1):20-28. doi: 10.1161/STROKEAHA.121.034505. Epub 2021 Sep 29. PmiD: 34583525.
  13. Law ZK, Tan HJ, Chin SP, Wong CY, Wan Yahya WNN, Muda AS, Zakaria R, Ariff mi, Ismail NA, Cheong SK, S Abdul Wahid SF, Mohamed Ibrahim N. The effects of intravenous infusion of autologous mesenchymal stromal cells in patients with subacute middle cerebral artery infarct: a phase 2 randomized controlled trial on safety, tolerability and efficacy. Cytotherapy. 2021 Sep;23(9):833-840. doi: 10.1016/j.jcyt.2021.03.005. Epub 2021 May 12. PmiD: 33992536.
  14. Chumnanvej S, Chumnanvej S. Autologous bone-marrow mononuclear stem cell therapy in patients with stroke: a meta-analysis of comparative studies. Biomed Eng Online. 2020 Sep 29;19(1):74. doi: 10.1186/s12938-020-00819-7. PmiD: 32993677; PMCID: PMC7526242.
  15. Gautam J, Alaref A, Hassan A, et al. (August 21, 2020) Safety and Efficacy of Stem Cell Therapy in Patients With Ischemic Stroke. Cureus 12(8): e9917. doi:10.7759/cureus.9917
  16. Jeong H, Yim HW, Cho YS, Kim YI, Jeong SN, Kim HB, Oh IH. Efficacy and safety of stem cell therapies for patients with stroke: a systematic review and single arm meta-analysis. International journal of stem cells. 2014 Nov 31;7(2):63-9.
  17. Wang Q, Duan F, Wang MX, Wang XD, Liu P, Ma LZ. Effect of stem cell-based therapy for ischemic stroke treatment: a meta-analysis. Clinical neurology and neurosurgery. 2016 Jul 1;146:1-1.
  18. Boncoraglio GB et al. Stem cell transplantation for ischemic stroke. Cochrane Database Syst Rev. 2019 May 5;5:CD007231.
  19. Abdullahi AM, Abdullahi IM, Sarmast ST, Bhriguvanshi A. Stem Cell Therapies for Ischemic Stroke: A Systematic Review. Cureus. 2021 Feb 4;13(2):e13139. doi: 10.7759/cureus.13139. PmiD: 33728153; PMCID: PMC7936858.
  20. Li Z, Dong X, Tian M, Liu C, Wang K, Li L, Liu Z, Liu J. Stem cell-based therapies for ischemic stroke: a systematic review and meta-analysis of clinical trials. Stem Cell Res Ther. 2020 Jun 26;11(1):252. doi: 10.1186/s13287-020-01762-z. PmiD: 32586371; PMCID: PMC7318436.
  21. Permana AT, Bajamal AH, Parenrengi MA, Suroto NS, Lestari P, Fauzi AA. Clinical outcome and safety of stem cell therapy for ischemic stroke: A systematic review and meta-analysis. Surg Neurol Int. 2022 May 20;13:206. doi: 10.25259/SNI_1174_2021. PmiD: 35673677; PMCID: PMC9168316.
  22. Turnbull MT, Zubair AC, Meschia JF, Freeman WD. Mesenchymal stem cells for hemorrhagic stroke: status of preclinical and clinical research. Npj Regenerative Medicine. 2019;4(1).
  23. Zhu J, Xiao Y, Li Z, Han F, Xiao T, Zhang Z, et al. Efficacy of surgery combined with autologous bone marrow stromal cell transplantation for treatment of intracerebral hemorrhage. Stem Cells Int. 2015;2015:318269.
  24. Kalladka D, Sinden J, Pollock K, Haig C, McLean J, Smith W, McConnachie A, Santosh C, Bath PM, Dunn L, Muir KW. Human neural stem cells in patients with chronic ischaemic stroke (PISCES): a phase 1, first-in-man study. The Lancet. 2016 Aug 20;388(10046):787-96.
  25. Rosado-de-Castro PH, Schmidt FR, Battistella V, Lopes de Souza SA, Gutfilen B, Goldenberg RC, Kasai-Brunswick TH, Vairo L, Silva RM, Wajnberg E, Do Brasil PE. Biodistribution of bone marrow mononuclear cells after intra-arterial or intravenous transplantation in subacute stroke patients. Regenerative medicine. 2013 Mar;8(2):145-55.
  26. Hammadi AM, Alhimyari F. Intra-Arterial Injection of Autologous Bone Marrow-Derived Mononuclear Cells in Ischemic Stroke Patients. Experimental and clinical transplantation: official journal of the middle East Society for Organ Transplantation. 2019 Jan;17(Suppl 1):239-41.
  27. Friedrich MA, Martins MP, Araújo MD, Klamt C, Vedolin L, Garicochea B, Raupp EF, Ammar JS, Machado DC, Da Costa JC, Nogueira RG. Intra-arterial infusion of autologous bone marrow mononuclear cells in patients with moderate to severe middle cerebral artery acute ischemic stroke. Cell transplantation. 2012 Jan;21(1_suppl):13-21.
  28. Savitz SI, misra V, Kasam M, Juneja H, Cox Jr CS, Alderman S, Aisiku I, Kar S, Gee A, Grotta JC. Intravenous autologous bone marrow mononuclear cells for ischemic stroke. Annals of neurology. 2011 Jul;70(1):59-69.
  29. Ghali AA, Yousef MK, Ragab OA, ElZamarany EA. Intra-arterial Infusion of Autologous Bone Marrow Mononuclear Stem Cells in Subacute Ischemic Stroke Patients. Front Neurol. 2016 Dec 16;7:228. doi: 10.3389/fneur.2016.00228. PubMed PmiD: 28018286; PubMed Central PMCID: PMC5159483.
  30. Savitz SI, Dinsmore J, Wu J, Henderson GV, Stieg P, Caplan LR. Neurotransplantation of fetal porcine cells in patients with basal ganglia infarcts: a preliminary safety and feasibility study. Cerebrovasc Dis. 2005;20(2):101–107. doi: 10.1159/000086518.
  31. Suarez-Monteagudo C, Hernandez-Ramirez P, Alvarez-Gonzalez L, Garcia-Maeso I, de la Cuetara-Bernal K, Castillo-Diaz L, et al. Autologous bone marrow stem cell neurotransplantation in stroke patients. An open study. Restor Neurol Neurosci. 2009;27(3):151–161.
  32. Barbosa da Fonseca LM, Gutfilen B, Rosado de Castro PH, Battistella V, Goldenberg RCS, Kasai-Brunswick T, et al. migration and homing of bone-marrow mononuclear cells in chronic ischemic stroke after intra-arterial injection. Exp Neurol. 2010;221(1):122–128. doi: 10.1016/j.expneurol.2009.10.010.
  33. Lee JS, Hong JM, Moon GJ, Lee PH, Ahn YH, Bang OY. A long-term follow-up study of intravenous autologous mesenchymal stem cell transplantation in patients with ischemic stroke. Stem Cells. 2010;28(6):1099–1106. doi: 10.1002/stem.430.
  34. Battistella V, de Freitas GR, da Fonseca LMB, Mercante D, Gutfilen B, Goldenberg RC, et al. Safety of autologous bone marrow mononuclear cell transplantation in patients with nonacute ischemic stroke. Regen Med. 2011;6(1):45–52. doi: 10.2217/rme.10.97.
  35. Honmou O, Houkin K, Matsunaga T, Niitsu Y, Ishiai S, Onodera R, et al. Intravenous administration of auto serum-expanded autologous mesenchymal stem cells in stroke. Brain. 2011;134(Pt 6):1790–1807. doi: 10.1093/brain/awr063.
  36. Savitz SI, misra V, Kasam M, Juneja H, Cox CS, Jr, Alderman S, et al. Intravenous autologous bone marrow mononuclear cells for ischemic stroke. Ann Neurol. 2011;70(1):59–69. doi: 10.1002/ana.22458.
  37. Taguchi A, Sakai C, Soma T, Kasahara Y, Stern DM, Kajimoto K, et al. Intravenous autologous bone marrow mononuclear cell transplantation for stroke: phase1/2a clinical trial in a homogeneous group of stroke patients. Stem Cells Dev. 2015;24(19):2207–2218. doi: 10.1089/scd.2015.0160.
  38. Steinberg GK, Kondziolka D, Wechsler LR, Lunsford LD, Coburn ML, Billigen JB, et al. Clinical outcomes of transplanted modified bone marrow-derived mesenchymal stem cells in stroke a phase 1/2a study. Stroke. 2016;47(7):1817–1824. doi: 10.1161/STROKEAHA.116.012995.
  39. Levy ML, Crawford JR, Dib N, Verkh L, Tankovich N, Cramer SC. Phase I/II Study of Safety and Preliminary Efficacy of Intravenous Allogeneic Mesenchymal Stem Cells in Chronic Stroke. Stroke. 2019 Oct;50(10):2835-2841. doi: 10.1161/STROKEAHA.119.026318. Epub 2019 Sep 9. PmiD: 31495331.
  40. Muir KW, Bulters D, Willmot M, Sprigg N, Dixit A, Ward N, Tyrrell P, Majid A, Dunn L, Bath P, Howell J, Stroemer P, Pollock K, Sinden J. Intracerebral implantation of human neural stem cells and motor recovery after stroke: multicentre prospective single-arm study (PISCES-2). J Neurol Neurosurg Psychiatry. 2020 Apr;91(4):396-401. doi: 10.1136/jnnp-2019-322515. Epub 2020 Feb 10. PmiD: 32041820; PMCID: PMC7147186.
  1. Brunet MC, Chen SH, Khandelwal P, Hare JM, Starke RM, Peterson EC, Yavagal DR. Intravenous Stem Cell Therapy for High-Grade Aneurysmal Subarachnoid Hemorrhage: Case Report and Literature Review. World Neurosurg. 2019 Aug;128:573-575. doi: 10.1016/j.wneu.2019.04.055. Epub 2019 Apr 11. PmiD: 30981798.
  2. Duma C, Kopyov O, Kopyov A, Berman M, Lander E, Elam M, Arata M, Weiland D, Cannell R, Caraway C, Berman S, Scord K, Stemler L, Chung K, Khoudari S, McRory R, Duma C, Farmer S, Bravo A, Yassa C, Sanathara A, Singh E, Rapaport B. Human intracerebroventricular (ICV) injection of autologous, non-engineered, adipose-derived stromal vascular fraction (ADSVF) for neurodegenerative disorders: results of a 3-year phase 1 study of 113 injections in 31 patients. Mol Biol Rep. 2019 Oct;46(5):5257-5272. doi: 10.1007/s11033-019-04983-5. Epub 2019 Jul 20. PmiD: 31327120.
  3. Vahidy FS, Haque ME, Rahbar MH, Zhu H, Rowan P, Aisiku IP, Lee DA, Juneja HS, Alderman S, Barreto AD, Suarez JI, Bambhroliya A, Hasan KM, Kassam MR, Aronowski J, Gee A, Cox CS Jr, Grotta JC, Savitz SI. Intravenous Bone Marrow Mononuclear Cells for Acute Ischemic Stroke: Safety, Feasibility, and Effect Size from a Phase I Clinical Trial. Stem Cells. 2019 Nov;37(11):1481-1491. doi: 10.1002/stem.3080. Epub 2019 Sep 17. PmiD: 31529663.
  4. Man Y, Li J, Yang B, Ma J. Vein transplantation using human umbilical cord blood stem cells in the treatment of stroke sequela. Neural Regeneration Research. 2006 Oct;1(7):618-21.
  5. Kawabori M, Shichinohe H, Kuroda S, Houkin K. Intracerebral Transplantation of Autologous Bone Marrow Stem Cell (BMSC) Against Acute Ischemic Stroke, Preliminary Data of Phase 1 Clinical Trial (RAINBOW Project). Stroke. 2020 Feb;51(Suppl_1):A45-.
  6. Qiao, L.-Y., Huang, F.-J., Zhao, M., Xie, J.-H., Shi, J., Wang, J., … Geng, T.-C. (2014). A Two-Year Follow-Up Study of Cotransplantation with Neural Stem/Progenitor Cells and Mesenchymal Stromal Cells in Ischemic Stroke Patients. Cell Transplantation, 23(1_suppl), 65–72.
  7. Chiu TL, Baskaran R, Tsai ST, Huang CY, Chuang MH, Syu WS, Harn HJ, Lin YC, Chen CH, Huang PC, Wang YF, Chuang CH, Lin PC, Lin SZ. Intracerebral transplantation of autologous adipose-derived stem cells for chronic ischemic stroke: A phase I study. J Tissue Eng Regen Med. 2022 Jan;16(1):3-13. doi: 10.1002/term.3256. Epub 2021 Oct 21. PmiD: 34644444.
  8. Muir KW, Bulters D, Willmot M, Sprigg N, Dixit A, Ward N, Tyrrell P, Majid A, Dunn L, Bath P, Howell J, Stroemer P, Pollock K, Sinden J. Intracerebral implantation of human neural stem cells and motor recovery after stroke: multicentre prospective single-arm study (PISCES-2). J Neurol Neurosurg Psychiatry. 2020 Apr;91(4):396-401. doi: 10.1136/jnnp-2019-322515. Epub 2020 Feb 10. PmiD: 32041820; PMCID: PMC7147186.
  9. Lee TK, Lu CY, Tsai ST, Tseng PH, Lin YC, Lin SZ, Wang JC, Huang CY, Chiu TL. Complete Restoration of Motor Function in Acute Cerebral Stroke Treated with Allogeneic Human Umbilical Cord Blood Monocytes: Preliminary Results of a phase I Clinical Trial. Cell Transplant. 2021 Jan-Dec;30:9636897211067447. PmiD: 34939863; PMCID: PMC8728774.
  10. Baak LM, Wagenaar N, van der Aa NE, Groenendaal F, Dudink J, Tataranno ML, Mahamuud U, Verhage CH, Eijsermans RMJC, Smit LS, Jellema RK, de Haan TR, Ter Horst HJ, de Boode WP, Steggerda SJ, Prins HJ, de Haar CG, de Vries LS, van Bel F, Heijnen CJ, Nijboer CH, Benders MJNL. Feasibility and safety of intranasally administered mesenchymal stromal cells after perinatal arterial ischaemic stroke in the Netherlands (PASSIoN): a first-in-human, open-label intervention study. Lancet Neurol. 2022 Jun;21(6):528-536. doi: 10.1016/S1474-4422(22)00117-X. PmiD: 35568047.
  11. Masamitsu, I., Masaki, T., Takashi, I., Narumi, N., Youko, S., Hitomi, T., Asami, U., Hiroko, T., Narumi, T., Takahito, N., Osamu, M., Hideya, A., & Ken-ichi Mizutani, N. (2020). Therapeutic effect of intravenously administered autologous Adipocyte-Derived stem cells on chronic stage stroke patients. International Journal of Stem Cell Research & Therapy, 7(1).
  12. Correa, P. L., Mesquita, C. T., Felix, R. M., Azevedo, J. C., Barbirato, G. B., Falcão, C. H., … Dohmann, H. F. (2007). Assessment of Intra-arterial Injected Autologous Bone Marrow Mononuclear Cell Distribution by Radioactive Labeling in Acute Ischemic Stroke. Clinical Nuclear Medicine, 32(11), 839–841.
  13. Ahn H, Lee SY, Jung WJ, Lee KH. Treatment of acute ischemic stroke by minimally manipulated umbilical cord-derived mesenchymal stem cells transplantation: A case report. World J Stem Cells. 2021 Aug 26;13(8):1151-1159. PmiD: 34567432; PMCID: PMC8422927.
  14. Le VC, Nguyen NH, Le SH. Intra-arterial infusion of autologous bone marrow mononuclear cells combined with intravenous injection of cerebrolysin in the treatment of middle cerebral artery ischemic stroke: Case report. SAGE Open Medical Case Reports. 2021;9.
  15. Zahra K, Turnbull MT, Zubair AC, Siegel JL, Venegas-Borsellino CP, Tawk RG, Freeman WD. A combined approach to intracerebral hemorrhage: intravenous mesenchymal stem cell therapy with minimally invasive hematoma evacuation. Journal of Stroke and Cerebrovascular Diseases. 2020 Aug 1;29(8):104931.
  16. Gao, X. (2021). A Case Report of Autologous Mesenchymal Stem Cells Treatment Improves The Recovery Of A Non-acute Ischemic Stroke patient (2581). Neurology, 96(15_supplement), 2581.
  17. Sheikh, A. M., Hossain, S., & Tabassum, S. (2024). Advances in stem cell therapy for stroke: mechanisms, challenges, and future directions. Regenerative Medicine Reports, 1(1), 76-92.
  18. Ya, J., Pellumbaj, J., Hashmat, A., & Bayraktutan, U. (2024). The role of stem cells as therapeutics for ischaemic stroke. Cells, 13(2), 112.
  19. Panos, L. D., Bargiotas, P., Arnold, M., Hadjigeorgiou, G., & Panos, G. D. (2024). Revolutionizing stroke recovery: unveiling the promise of stem cell therapy. Drug Design, Development and Therapy, 991-1006.
  20. Houkin, K., Osanai, T., Uchiyama, S., Minematsu, K., Taguchi, A., Maruichi, K., ... & TREASURE Study Investigators. (2024). Allogeneic stem cell therapy for acute ischemic stroke: the phase 2/3 TREASURE randomized clinical trial. JAMA neurology, 81(2), 154-162.
  21. Nie, L., Yao, D., Chen, S., Wang, J., Pan, C., Wu, D., ... & Tang, Z. (2023). Directional induction of neural stem cells, a new therapy for neurodegenerative diseases and ischemic stroke. Cell Death Discovery, 9(1), 215.
  22. Wang, S., He, Q., Qu, Y., Yin, W., Zhao, R., Wang, X., ... & Guo, Z. N. (2024). Emerging strategies for nerve repair and regeneration in ischemic stroke: neural stem cell therapy. Neural Regeneration Research, 19(11), 2430-2443.
  23. Markowska, A., Koziorowski, D., & Szlufik, S. (2023). Microglia and stem cells for ischemic stroke treatment—mechanisms, current status, and therapeutic challenges. Frontiers in Bioscience-Landmark, 28(10), 269.
  24. Mani, K. K., El-Hakim, Y., Branyan, T. E., Samiya, N., Pandey, S., Grimaldo, M. T., ... & Sohrabji, F. (2023). Intestinal epithelial stem cell transplants as a novel therapy for cerebrovascular stroke. Brain, behavior, and immunity, 107, 345-360.
  25. Tang, H., Li, Y., Tang, W., Zhu, J., Parker, G. C., & Zhang, J. H. (2023). Endogenous neural stem cell–induced neurogenesis after ischemic stroke: processes for brain repair and perspectives. Translational Stroke Research, 14(3), 297-303.