Spinal Cord Injury Publications International

1. Fan X, Wang JZ, Lin XM, Zhang L. Stem cell transplantation for spinal cord injury: a meta-analysis of treatment effectiveness and safety. Neural Regen Res. 2017 May;12(5):815-825. doi: 10.4103/1673-5374.206653. PubMed PmiD: 28616040; PubMed Central PMCID: PMC5461621.
2. Xu P, Yang X. The Efficacy and Safety of Mesenchymal Stem Cell Transplantation for Spinal Cord Injury Patients: A Meta-Analysis and Systematic Review. Cell Transplant. 2019 Jan;28(1):36-46. doi: 10.1177/0963689718808471. Epub 2018 Oct 26. PubMed PmiD: 30362373; PubMed Central PMCID: PMC6322141.
3. Cheng H, Liu X, Hua R, Dai G, Wang X, Gao J, An Y. Clinical observation of umbilical cord mesenchymal stem cell transplantation in treatment for sequelae of thoracolumbar spinal cord injury. J Transl Med. 2014 Sep 12;12:253. doi: 10.1186/s12967-014-0253-7. PubMed PmiD: 25209445; PubMed Central PMCID: PMC4172930.
4. Albu S, Kumru H, Coll R, Vives J, Vallés M, Benito-Penalva J, Rodríguez L, Codinach M, Hernández J, Navarro X, Vidal J. Clinical effects of intrathecal administration of expanded Wharton jelly mesenchymal stromal cells in patients with chronic complete spinal cord injury: a randomized controlled study. Cytotherapy. 2021 Feb;23(2):146-156. doi: 10.1016/j.jcyt.2020.08.008. Epub 2020 Sep 25. PmiD: 32981857.
5. Li XC, Zhong CF, Deng GB, Liang RW, Huang CM. Efficacy and safety of bone marrow-derived cell transplantation for spinal cord injury: a systematic review and meta-analysis of clinical trials. Clin Transplant. 2015;29:786–795.
6. Tang QR, Xue H, Zhang Q, Guo Y, Xu H, Liu Y, Liu JM. Evaluation of the Clinical Efficacy of Stem Cell Transplantation in the Treatment of Spinal Cord Injury: A Systematic Review and Meta-analysis. Cell Transplant. 2021 Jan-Dec;30:9636897211067804. doi: 10.1177/09636897211067804. PmiD: 34939443; PMCID: PMC8725233.
7. Chen WC, Liu WF, Bai YY, Zhou YY, Zhang Y, Wang CM, Lin S, He HF. Transplantation of mesenchymal stem cells for spinal cord injury: a systematic review and network meta-analysis. J Transl Med. 2021 Apr 28;19(1):178. doi: 10.1186/s12967-021-02843-0. PmiD: 33910588; PMCID: PMC8082850.
8. Liu S, Zhang H, Wang H, Huang J, Yang Y, Li G, Yu K, Yang L. A Comparative Study of Different Stem Cell Transplantation for Spinal Cord Injury: A Systematic Review and Network Meta-Analysis. World Neurosurg. 2022 Mar;159:e232-e243. doi: 10.1016/j.wneu.2021.12.035. Epub 2021 Dec 22. PmiD: 34954058.
9. Yoon SH, Shim YS, Park YH, Chung JK, Nam JH, Kim MO, Park HC, Park SR, Min BH, Kim EY, Choi BH. Complete spinal cord injury treatment using autologous bone marrow cell transplantation and bone marrow stimulation with granulocyte macrophage‐colony stimulating factor: phase I/II clinical trial. Stem cells. 2007 Aug;25(8):2066-73.
10. Frolov AA, Bryukhovetskiy AS. Effects of hematopoietic autologous stem cell transplantation to the chronically injured human spinal cord evaluated by motor and somatosensory evoked potentials methods. Cell transplantation. 2012 Jan;21(1_suppl):49-55.
11. Bryukhovetskiy AS, Bryukhovetskiy IS. Effectiveness of repeated transplantations of hematopoietic stem cells in spinal cord injury. World journal of transplantation. 2015 Sep 24;5(3):110.
12. Chernykh ER, Stupak VV, Muradov GM, Sizikov MY, Shevela EY, Leplina OY, Tikhonova MA, Kulagin AD, Lisukov IA, Ostanin AA, Kozlov VA. Application of autologous bone marrow stem cells in the therapy of spinal cord injury patients. Bulletin of experimental biology and medicine. 2007 Apr 1;143(4):543-7.
13. Tabakow P, Jarmundowicz W, Czapiga B, Fortuna W, Miedzybrodzki R, Czyz M, Huber J, Szarek D, Okurowski S, Szewczyk P, Gorski A. Transplantation of autologous olfactory ensheathing cells in complete human spinal cord injury. Cell transplantation. 2013 Sep;22(9):1591-612.
14. Mackay-Sim A, Feron F, Cochrane J, Bassingthwaighte L, Bayliss C, Davies W, Fronek P, Gray C, Kerr G, Licina P, Nowitzke A. Autologous olfactory ensheathing cell transplantation in human paraplegia: a 3-year clinical trial. Brain. 2008 Aug 8;131(9):2376-86.
15. Abdelaziz OS, Marie A, Abbas M, Ibrahim M, Gabr H. Feasibility, safety, and efficacy of directly transplanting autologous adult bone marrow stem cells in patients with chronic traumatic dorsal cord injury: a pilot clinical study. Neurosurgery Quarterly. 2010 Sep 1;20(3):216-26.
16. Dai G, Liu X, Zhang Z, Yang Z, Dai Y, Xu R. Transplantation of autologous bone marrow mesenchymal stem cells in the treatment of complete and chronic cervical spinal cord injury. Brain research. 2013 Oct 2;1533:73-9.
17. Karamouzian S, Nematollahi-Mahani SN, Nakhaee N, Eskandary H. Clinical safety and primary efficacy of bone marrow mesenchymal cell transplantation in subacute spinal cord injured patients. Clinical neurology and neurosurgery. 2012 Sep 1;114(7):935-9.
18. Kishk NA, Gabr H, Hamdy S, Afifi L, Abokresha N, Mahmoud H, Wafaie A, Bilal D. Case control series of intrathecal autologous bone marrow mesenchymal stem cell therapy for chronic spinal cord injury. Neurorehabil Neural Repair. 2010;24(8):702–708.
19. Deda H, Inci MC, Kürekçi AE, Kayıhan K, Özgün E, Üstünsoy G, Kocabay S. Treatment of chronic spinal cord injured patients with autologous bone marrow-derived hematopoietic stem cell transplantation: 1-year follow-up. Cytotherapy. 2008 Jan 1;10(6):565-74.
20. Park JH, Kim DY, Sung IY, Choi GH, Jeon MH, Kim KK, Jeon SR. Long-term results of spinal cord injury therapy using mesenchymal stem cells derived from bone marrow in humans. Neurosurgery. 2011 Nov 29;70(5):1238-47.
21. Cristante AF, Barros-Filho TE, Tatsui N, Mendrone A, Caldas JG, Camargo A, Alexandre A, Teixeira WG, Oliveira RP, Marcon RM. Stem cells in the treatment of chronic spinal cord injury: evaluation of somatosensitive evoked potentials in 39 patients. Spinal Cord. 2009 Oct;47(10):733.
22. Zhou XH, Ning GZ, Feng SQ, Kong XH, Chen JT, Zheng YF, Ban DX, Liu T, Li H, Wang P. Transplantation of autologous activated Schwann cells in the treatment of spinal cord injury: six cases, more than five years of follow-up. Cell transplantation. 2012 Jan;21(1_suppl):39-47.
23. Saberi H, Firouzi M, Habibi Z, Moshayedi P, Aghayan HR, Arjmand B, Hosseini K, Razavi HE, Yekaninejad MS. Safety of intramedullary Schwann cell transplantation for postrehabilitation spinal cord injuries: 2-year follow-up of 33 cases. Journal of Neurosurgery: Spine. 2011 Nov 1;15(5):515-25.
24. Derakhshanrad N, Saberi H, Shafiee S, Yekaninejad MS, Hadian MR, Sheikhrezai A, Khan ZH, Javidan AN, Kohan AH. Safety of intramedullary autologous peripheral nerve grafts for post-rehabilitated complete motor spinal cord injuries: a phase I study. Acta Medica Iranica. 2013:842-54.
25. Huang H, Xi H, Chen L, Zhang F, Liu Y. Long-term outcome of olfactory ensheathing cell therapy for patients with complete chronic spinal cord injury. Cell transplantation. 2012 Jan;21(1_suppl):23-31.
26. Attar A, Ayten M, Ozdemir M, Ozgencil E, Bozkurt M, Kaptanoglu E, Beksac M, Kanpolat Y. An attempt to treat patients who have injured spinal cords with intralesional implantation of concentrated autologous bone marrow cells. Cytotherapy. 2011 Jan 1;13(1):54-60.
27. Pal R, Venkataramana NK, Bansal A, Balaraju S, Jan M, Chandra R, Dixit A, Rauthan A, Murgod U, Totey S. Ex vivo-expanded autologous bone marrow-derived mesenchymal stromal cells in human spinal cord injury/paraplegia: a pilot clinical study. Cytotherapy. 2009 Jan 1;11(7):897-911.
28. Syková E, Homola A, Mazanec R, Lachmann H, Konrádová ŠL, Kobylka P, Pádr R, Neuwirth J, Komrska V, Vávra V, Štulík J. Autologous bone marrow transplantation in patients with subacute and chronic spinal cord injury. Cell transplantation. 2006 Sep;15(8-9):675-87.
29. Lima C, Escada P, Pratas-Vital J, Branco C, Arcangeli CA, Lazzeri G, Santana Maia CA, Capucho C, Hasse-Ferreira A, Peduzzi JD. Olfactory mucosal autografts and rehabilitation for chronic traumatic spinal cord injury. Neurorehabilitation and neural repair. 2010 Jan;24(1):10-22.
30. Saberi H, Moshayedi P, Aghayan HR, Arjmand B, Hosseini SK, Emami-Razavi SH, Rahimi-Movaghar V, Raza M, Firouzi M. Treatment of chronic thoracic spinal cord injury patients with autologous Schwann cell transplantation: an interim report on safety considerations and possible outcomes. Neuroscience letters. 2008 Sep 26;443(1):46-50.
31. Saito F, Nakatani T, Iwase M, Maeda Y, Murao Y, Suzuki Y, Fukushima M, Ide C. Administration of cultured autologous bone marrow stromal cells into cerebrospinal fluid in spinal injury patients: a pilot study.
32. Moviglia GA, Fernandez Vina R, Brizuela JA, Saslavsky J, Vrsalovic F, Varela G, Bastos F, Farina P, Etchegaray G, Barbieri M, Martinez G. Combined protocol of cell therapy for chronic spinal cord injury. Report on the electrical and functional recovery of two patients. Cytotherapy. 2006 Jan 1;8(3):202-9.
33. Huang H, Chen L, Wang H, Xiu B, Li B, Wang R, Zhang J, Zhang F, Gu Z, Li Y, Song Y. Influence of patients' age on functional recovery after transplantation of olfactory ensheathing cells into injured spinal cord injury. Chinese medical journal. 2003 Oct;116(10):1488-91.
34. Ha Y, Yoon SH, Park SR, Cho YE, Yoon DH, Park HC. Treatment of Complete Spinal Cord Injury Patients Receiving Autologous Bone Marrow Cell Transplantation and Bone Marrow Stimulation with Granulocyte Macrophage-Colony Stimulating Factor: Report of Three Cases. Journal of Korean Neurosurgical Society. 2004 May 1;35(5):459-64.
35. Knoller N, Auerbach G, Fulga V, Zelig G, Attias J, Bakimer R, Marder JB, Yoles E, Belkin M, Schwartz M, Hadani M. Clinical experience using incubated autologous macrophages as a treatment for complete spinal cord injury: phase I study results. Journal of Neurosurgery: Spine. 2005 Sep 1;3(3):173-81.

36. Jiang PC, Xiong WP, Wang G, Ma C, Yao WQ, Kendell SF, Mehling BM, Yuan XH, Wu DC. A clinical trial report of autologous bone marrow-derived mesenchymal stem cell transplantation in patients with spinal cord injury. Experimental and therapeutic medicine. 2013 Jul 1;6(1):140-6.
37. Rao Y, Zhu W, Liu H, Jia C, Zhao Q, Wang Y. Clinical application of olfactory ensheathing cells in the treatment of spinal cord injury. Journal of International Medical Research. 2013 Apr;41(2):473-81.
38. Yazdani SO, Hafizi M, Zali AR, Atashi A, Ashrafi F, Seddighi AS, Soleimani M. Safety and possible outcome assessment of autologous Schwann cell and bone marrow mesenchymal stromal cell co-transplantation for treatment of patients with chronic spinal cord injury. Cytotherapy. 2013 Jul 1;15(7):782-91.
39. Liu J, Han D, Wang Z, Xue M, Zhu L, Yan H, Zheng X, Guo Z, Wang H. Clinical analysis of the treatment of spinal cord injury with umbilical cord mesenchymal stem cells. Cytotherapy. 2013 Feb 1;15(2):185-91.
40. Wu J, Sun T, Ye C, Yao J, Zhu B, He H. Clinical observation of fetal olfactory ensheathing glia transplantation (OEGT) in patients with complete chronic spinal cord injury. Cell transplantation. 2012 Jan;21(1_suppl):33-7.
41. Huang H, Chen L, Wang H, Xi H, Gou C, Zhang J, Zhang F, Liu Y. Safety of fetal olfactory ensheathing cell transplantation in patients with chronic spinal cord injury. A 38-month follow-up with MRI. Zhongguo xiu fu chong jian wai ke za zhi = Chinese journal of reparative and reconstructive surgery. 2006;20(4):439-443.
42. Huang H, Wang H, Chen L, Gu Z, Zhang J, Zhang F, Song Y, Li Y, Tan K, Liu Y, Xi H. Influence factors for functional improvement after olfactory ensheathing cell transplantation for chronic spinal cord injury. Zhongguo xiu fu chong jian wai ke za zhi = Chinese journal of reparative and reconstructive surgery. 2006;20(4):434-438.
43. Mendonça MV, Larocca TF, de Freitas Souza BS, Villarreal CF, Silva LF, Matos AC, Novaes MA, Bahia CM, Martinez AC, Kaneto CM, Furtado SB. Safety and neurological assessments after autologous transplantation of bone marrow mesenchymal stem cells in subjects with chronic spinal cord injury. Stem cell research & therapy. 2014 Dec;5(6):126.
44. Park HC, Shim YS, Ha Y, Yoon SH, Park SR, Choi BH, Park HS. Treatment of complete spinal cord injury patients by autologous bone marrow cell transplantation and administration of granulocyte-macrophage colony stimulating factor. Tissue Engineering. 2005 May 1;11(5-6):913-22.
45. Suzuki Y, Ishikawa N, Omae K, Hirai T, Ohnishi K, Nakano N, Nishida H, Nakatani T, Fukushima M, Ide C. Bone marrow-derived mononuclear cell transplantation in spinal cord injury patients by lumbar puncture. Restorative neurology and neuroscience. 2014 Jan 1;32(4):473-82.
46. Rabinovich SS, Seledtsov VI, Poveschenko OV, Senuykov VV, Taraban VY, Yarochno VI, Kolosov NG, Savchenko SA, Kozlov VA. Transplantation treatment of spinal cord injury patients. Biomedicine & pharmacotherapy. 2003 Nov 1;57(9):428-33.
47. Lima C, Pratas-Vital J, Escada P, Hasse-Ferreira A, Capucho C, Peduzzi JD. Olfactory mucosa autografts in human spinal cord injury: a pilot clinical study. The journal of spinal cord medicine. 2006 Jan 1;29(3):191-203.
48. Deda H, Inci MC, Kürekçi AE, Kayıhan K, Özgün E, Üstünsoy G, Kocabay S. Treatment of chronic spinal cord injured patients with autologous bone marrow-derived hematopoietic stem cell transplantation: 1-year follow-up. Cytotherapy. 2008 Jan 1;10(6):565-74.
49. Zamani H, Soufizomorrod M, Oraee-Yazdani S, Naviafar D, Akhlaghpasand M, Seddighi A, Soleimani M. Safety and feasibility of autologous olfactory ensheathing cell and bone marrow mesenchymal stem cell co-transplantation in chronic human spinal cord injury: a clinical trial. Spinal Cord. 2022 Jan;60(1):63-70.
50. Honmou O, Yamashita T, Morita T, Oshigiri T, Hirota R, Iyama S, Kato J, Sasaki Y, Ishiai S, Ito YM, Namioka A, Namioka T, Nakazaki M, Kataoka-Sasaki Y, Onodera R, Oka S, Sasaki M, Waxman SG, Kocsis JD. Intravenous infusion of auto serum-expanded autologous mesenchymal stem cells in spinal cord injury patients: 13 case series. Clin Neurol Neurosurg. 2021 Apr;203:106565.
51. Smirnov VA, Radaev SM, Morozova YV, Ryabov SI, Yadgarov MY, Bazanovich SA, Lvov IS, Talypov AE, Grin AA. Systemic Administration of Allogeneic Cord Blood Mononuclear Cells in Adults with Severe Acute Contusion Spinal Cord Injury: Phase 1/2a Pilot Clinical Study-Safety and Primary Efficacy Evaluation. World Neurosurg. 2022 May;161:e319-e338.
52. McKenna SL, Ehsanian R, Liu CY, Steinberg GK, Jones L, Lebkowski JS, Wirth E, Fessler RG. Ten-year safety of pluripotent stem cell transplantation in acute thoracic spinal cord injury. Journal of Neurosurgery: Spine. 2022 Apr 1;1(aop):1-0.
53. Martin J, Curtis E, Cleary D, Mendoza M, Jamieson C, Marsala M, Ciacci JD. 179 Clinical Outcomes From a Single-Site Phase I Study of Neural Stem Cell Transplantation for Chronic Spinal Cord Injury. Neurosurgery. 2022 Apr 1;68(Supplement_1):53-4.
54. Geffner LF, Santacruz P, Izurieta M, Flor L, Maldonado B, Auad AH, Montenegro X, Gonzalez R, Silva F. Administration of autologous bone marrow stem cells into spinal cord injury patients via multiple routes is safe and improves their quality of life: comprehensive case studies. Cell transplantation. 2008 Dec;17(12):1277-93.
55. Milczarek O, Kwiatkowski S, Swadłba J, Swadžba P, Kwiatkowska K, Majka M. Use of Multiple Wharton Jelly Mesenchymal Stem Cell Transplants in Treatment of Incomplete Spinal Cord Injury: A Case Report. Exp Clin Transplant. 2022 Jul 22.
56. Derakhshanrad N, Saberi H, Tayebi Meybodi K, Taghvaei M, Arjmand B, Aghayan HR, Kohan AH, Haghpanahi M, Rahmani S. Case Report: Combination Therapy with Mesenchymal Stem Cells and Granulocyte-Colony Stimulating Factor in a Case of Spinal Cord Injury. Basic Clin Neurosci. 2015 Oct;6(4):299-305.
57. Ichim TE, Solano F, Lara F, Paris E, Ugalde F, Rodriguez J, Minev B, Bogin V, Ramos F, Woods EJ, Murphy MP, Patel AN, Harman RJ, Riordan NH. Feasibility of combination allogeneic stem cell therapy for spinal cord injury: a case report. International Archives of Medicine. 2010;3(1):30.
58. Chotivichit A, Ruangchainikom M, Chiewvit P, Wongkajornsilp A, Sujirattanawimol K. Chronic spinal cord injury treated with transplanted autologous bone marrow-derived mesenchymal stem cells tracked by magnetic resonance imaging: a case report. Journal of Medical Case Reports. 2015 Dec;9(1):1-7.
59. Moviglia G, Varela G, Brizuela J, et al. Case report on the clinical results of a combined cellular therapy for chronic spinal cord injured patients. Spinal Cord. 2009;47:499–503.
60. Xia Y, Zhu J, Yang R, Wang H, Li Y, Fu C. Mesenchymal stem cells in the treatment of spinal cord injury: Mechanisms, current advances and future challenges. Frontiers in immunology. 2023;14:1141601.
61. Hosseini SM, Borys B, Karimi-Abdolrezaee S. Neural stem cell therapies for spinal cord injury repair: an update on recent preclinical and clinical advances. Brain. 2024;147(3):766-793.
62. Yao S, Pang M, Wang Y, Wang X, Lin Y, Lv Y, Rong L. Mesenchymal stem cell attenuates spinal cord injury by inhibiting mitochondrial quality control-associated neuronal ferroptosis. Redox biology. 2023;67:102871.
63. Li Z, Zhao T, Ding J, Gu H, Wang Q, Wang Y, Gao C. A reactive oxygen species-responsive hydrogel encapsulated with bone marrow derived stem cells promotes repair and regeneration of spinal cord injury. Bioactive materials. 2023;19:550-568.
64. Gao C, Li Y, Liu X, Huang J, Zhang Z. 3D bioprinted conductive spinal cord biomimetic scaffolds for promoting neuronal differentiation of neural stem cells and repairing of spinal cord injury. Chemical Engineering Journal. 2023;451:138788.
65. Ying Y, Huang Z, Tu Y, Wu Q, Li Z, Zhang Y, Wang Z. A shear-thinning, ROS-scavenging hydrogel combined with dental pulp stem cells promotes spinal cord repair by inhibiting ferroptosis. Bioactive materials. 2023;22:274-290.
66. Montoto-Meijide R, Meijide-Failde R, Diaz-Prado SM, Montoto-Marques A. Mesenchymal stem cell therapy in traumatic spinal cord injury: a systematic review. International Journal of Molecular Sciences. 2023;24(14):11719.
67. Li J, Luo W, Xiao C, Zhao J, Xiang C, Liu W, Gu R. Recent advances in endogenous neural stem/progenitor cell manipulation for spinal cord injury repair. Theranostics. 2023;13(12):3966.
68. Zeng CW. Advancing spinal cord injury treatment through stem cell therapy: a comprehensive review of cell types, challenges, and emerging technologies in regenerative medicine. International Journal of Molecular Sciences. 2023;24(18):14349.
69. Hu X, Xu W, Ren Y, Wang Z, He X, Huang R, Cheng L. Spinal cord injury: molecular mechanisms and therapeutic interventions. Signal transduction and targeted therapy. 2023;8(1):245.