Society of Regenerative Sciences (India)

(Formerly known as Stem Cell Society (India))

Event Registration Membership Form

International Publications On Diabetes

Diabetes Publications

  1. El-Badawy, A., & El-Badri, N. (2016). Clinical Efficacy of Stem cell therapy for Diabetes Mellitus: A Meta-Analysis. PLoS ONE, 11(4), e0151938. doi: 10.1371/journal.pone.015193
  2. Ranjbaran H, Mohammadi Jobani B, Amirfakhrian E, Alizadeh-Navaei R. Efficacy of mesenchymal stem cell therapy on glucose levels in type 2 diabetes mellitus: A systematic review and meta-analysis. J Diabetes Investig. 2021 May;12(5):803-810. doi: 10.1111/jdi.13404. Epub 2020 Oct 22. PmiD: 32926576; PMCID: PMC8089007.
  3. Zhang Y, Chen W, Feng B, Cao H. The Clinical Efficacy and Safety of Stem Cell Therapy for Diabetes Mellitus: A Systematic Review and Meta-Analysis. Aging Dis. 2020 Feb 1;11(1):141-153. doi: 10.14336/AD.2019.0421. PmiD: 32010488; PMCID: PMC6961772.
  4. He J, Kong D, Yang Z, Guo R, Amponsah AE, Feng B, Zhang X, Zhang W, Liu A, Ma J, O'Brien T, Cui H. Clinical efficacy on glycemic control and safety of mesenchymal stem cells in patients with diabetes mellitus: Systematic review and meta-analysis of RCT data. PLoS One. 2021 Mar 11;16(3):e0247662. doi: 10.1371/journal.pone.0247662. PmiD: 33705413; PMCID: PMC7951834.
  5. Wu Q, Zheng S, Qin Y, Zheng X, Chen H, Yang T, Zhang M. Efficacy and safety of stem cells transplantation in patients with type 1 diabetes mellitus-a systematic review and meta-analysis. Endocr J. 2020 Aug 28;67(8):827-840. doi: 10.1507/endocrj.EJ20-0050. Epub 2020 May 23. PmiD: 32321876.
  6. Madani S, Amanzadi M, Aghayan HR, Setudeh A, Rezaei N, Rouhifard M, Larijani B. Investigating the safety and efficacy of hematopoietic and mesenchymal stem cell transplantation for treatment of T1DM: a systematic review and meta-analysis. Syst Rev. 2022 May 2;11(1):82. doi: 10.1186/s13643-022-01950-3. PmiD: 35501872; PMCID: PMC9059401.
  7. Rahim F, Arjmand B, Shirbandi K, Payab M, Larijani B. Stem cell therapy for patients with diabetes: a systematic review and meta-analysis of metabolomics-based risks and benefits. Non-coding RNA Investigation. 2018;2:40. doi: 10.21037/sci.2018.11.01
  8. Gan J, Wang Y, Zhou X. Stem cell transplantation for the treatment of patients with type 1 diabetes mellitus: A meta-analysis. Experimental and Therapeutic Medicine. 2018. doi: 10.3892/etm.2018.6769
  9. Hu J, Yu X, Wang Z, Wang F, Wang L, Gao H, Chen Y, Zhao W, Jia Z, Yan S, Wang Y. Long term effects of the implantation of Wharton’s jelly-derived mesenchymal stem cells from the umbilical cord for newly-onset type 1 diabetes mellitus. Endocrine Journal. 2012;60(3):347–357. doi: 10.1507/endocrj.ej12-0343
  10. Carlsson P, Schwarcz E, Korsgren O, Blanc KL. Preserved Β-Cell function in Type 1 diabetes by mesenchymal stromal cells. Diabetes. 2014;64(2):587–592. doi: 10.2337/db14-0656
  11. Cai J, Wu Z, Xu X, Liao L, Chen J, Huang L, Wu W, Luo F, Wu C, Pugliese A, Pileggi A, Ricordi C, Tan J. Umbilical cord mesenchymal stromal cell with autologous bone marrow cell Transplantation in established Type 1 diabetes: A pilot randomized controlled Open-Label clinical study to assess safety and impact on insulin secretion. Diabetes Care. 2015;39(1):149–157. doi: 10.2337/dc15-0171
  12. Skyler JS, Fonseca VA, Segal KR, Rosenstock J. Allogeneic mesenchymal precursor cells in Type 2 diabetes: A randomized, Placebo-Controlled, Dose-Escalation Safety and Tolerability pilot study. Diabetes Care. 2015;38(9):1742–1749. doi: 10.2337/dc14-2830
  13. Packham DK, Fraser IR, Kerr PG, Segal KR. Allogeneic Mesenchymal Precursor Cells (MPC) in Diabetic nephropathy: A randomized, placebo-controlled, dose escalation study. EBioMedicine. 2016;12:263–269. doi: 10.1016/j.ebiom.2016.09.011
  14. Haller MJ, Wasserfall CH, Hulme MA, Cintron M, Brusko TM, McGrail KM, Wingard JR, Theriaque DW, Shuster JJ, Ferguson RJ, Kozuch M, Clare-Salzler M, Atkinson MA, Schatz DA. Autologous Umbilical Cord Blood Infusion followed by Oral Docosahexaenoic Acid and Vitamin D Supplementation for C-Peptide Preservation in Children with Type 1 Diabetes. Biology of Blood and Marrow Transplant. 2013;19(7):1126–1129. doi: 10.1016/j.bbmt.2013.04.011
  15. Wu Z, Cai J, Chen J, Huang L, Wu W, Luo F, Wu C, Liao L, Tan J. Autologous bone marrow mononuclear cell infusion and hyperbaric oxygen therapy in type 2 diabetes mellitus: an open-label, randomized controlled clinical trial. Cytotherapy. 2013;16(2):258–265. doi: 10.1016/j.jcyt.2013.10.004
  16. Estrada EJ, Decima JL, Bortman G, Roberti J, Romero EB, Samaja G, Saavedra AR, Martínez G, Gutiérrez S. Combination treatment of autologous bone marrow stem cell transplantation and hyperbaric oxygen therapy for type 2 diabetes mellitus: A randomized controlled trial. Cell Transplant. 2019 Dec;28(12):1632-1640. doi: 10.1177/0963689719883813. Epub 2019 Oct 30. PmiD: 31665912; PMCID: PMC6923554.
  17. Izadi M, Sadr Hashemi Nejad A, Moazenchi M, Masoumi S, Rabbani A, Kompani F, Hedayati Asl AA, Abbasi Kakroodi F, Jaroughi N, Mohseni Meybodi MA, Setoodeh A, Abbasi F, Hosseini SE, Moeini Nia F, Salman Yazdi R, Navabi R, Hajizadeh-Saffar E, Baharvand H. Mesenchymal stem cell transplantation in newly diagnosed type-1 diabetes patients: a phase I/II randomized placebo-controlled clinical trial. Stem Cell Res Ther. 2022 Jun 20;13(1):264. doi: 10.1186/s13287-022-02941-w. PmiD: 35725652; PMCID: PMC9208234.
  18. Zang L, Li Y, Hao H, Liu J, Cheng Y, Li B, Yin Y, Zhang Q, Gao F, Wang H, Gu S, Li J, Lin F, Zhu Y, Tian G, Chen Y, Gu W, Du J, Chen K, Guo Q, Yang G, Pei Y, Yan W, Wang X, Meng J, Zhang S, Ba J, Lyu Z, Dou J, Han W, Mu Y. Efficacy and safety of umbilical cord-derived mesenchymal stem cells in Chinese adults with type 2 diabetes: a single-center, double-blinded, randomized, placebo-controlled phase II trial. Stem Cell Res Ther. 2022 May 3;13(1):180. doi: 10.1186/s13287-022-02848-6. PmiD: 35505375; PMCID: PMC9066971.
  19. Nguyen LT, Hoang DM, Nguyen KT, Bui DM, Nguyen HT, Le HTA, Hoang VT, Bui HTH, Dam PTM, Hoang XTA, Ngo ATL, Le HM, Phung NY, Vu DM, Duong TT, Nguyen TD, Ha LT, Bui HTP, Nguyen HK, Heke M, Bui AV. Type 2 diabetes mellitus duration and obesity alter the efficacy of autologously transplanted bone marrow-derived mesenchymal stem/stromal cells. Stem Cells Transl Med. 2021 Sep;10(9):1266-1278. doi: 10.1002/sctm.20-0506. Epub 2021 Jun 3. PmiD: 34080789; PMCID: PMC8380443.
  20. Wu Z, Xu X, Cai J, Chen J, Huang L, Wu W, Pugliese A, Li S, Ricordi C, Tan J. Prevention of chronic diabetic complications in type 1 diabetes by co-transplantation of umbilical cord mesenchymal stromal cells and autologous bone marrow: a pilot randomized controlled open-label clinical study with 8-year follow-up. Cytotherapy. 2022 Apr;24(4):421-427. doi: 10.1016/j.jcyt.2021.09.015. Epub 2022 Jan 25. PmiD: 35086778.
  21. Li Y, Wang F, Liang H, Tang D, Huang M, Zhao J, Yang X, Liu Y, Shu L, Wang J, He Z, Liu Y. Efficacy of mesenchymal stem cell transplantation therapy for type 1 and type 2 diabetes mellitus: a meta-analysis. Stem Cell Res Ther. 2021 May 6;12(1):273. doi: 10.1186/s13287-021-02342-5. PmiD: 33957998; PMCID: PMC8101194.
  22. Sun SY, Gao Y, Liu GJ, Li YK, Gao W, Ran XW. Efficacy and Safety of Stem Cell Therapy for T1DM: An Updated Systematic Review and Meta-Analysis. J Diabetes Res. 2020 Oct 10;2020:5740923. doi: 10.1155/2020/5740923. PmiD: 33102605; PMCID: PMC7569432.
  23. Ye L, Li L, Wan B, Yang M, Hong J, Gu W, Wang W, Ning G. Immune response after autologous hematopoietic stem cell transplantation in type 1 diabetes mellitus. Stem Cell Research & Therapy. 2017;8(1). doi: 10.1186/s13287-017-0542-1
  24. Liu X, Zheng P, Wang X, Dai G, Cheng H, Zhang Z, Hua R, Niu X, Shi J, An Y. A preliminary evaluation of efficacy and safety of Wharton’s jelly mesenchymal stem cell transplantation in patients with type 2 diabetes mellitus. Stem Cell Research & Therapy. 2014;5(2). doi: 10.1186/scrt446
  25. D’Addio F, Vasquez AV, Nasr MB, Franek E, Zhu D, Li L, Ning G, Snarski E, Fiorina P. Autologous nonmyeloablative hematopoietic stem cell transplantation in New-Onset Type 1 Diabetes: a Multicenter analysis. Diabetes. 2014;63(9):3041–3046. doi: 10.2337/db14-0295
  26. Gu B, Miao H, Zhang J, Hu J, Zhou W, Gu W, Wang W, Ning G. Clinical benefits of autologous haematopoietic stem cell transplantation in type 1 diabetes patients. Diabetes & Metabolism. 2017;44(4):341–345. doi: 10.1016/j.diabet.2017.12.006
  27. Voltarelli JC, Couri CEB, Stracieri ABPL, Oliveira MC, Moraes DA, Pieroni F, Coutinho M, Malmegrim KCR, Foss-Freitas MC, Simões BP, Foss MC, Squiers E, Burt RK. Autologous nonmyeloablative hematopoietic stem cell transplantation in newly diagnosed type 1 diabetes mellitus. JAMA. 2007;297(14):1568. doi: 10.1001/jama.297.14.1568
  28. Zhao Y, Jiang Z, Zhao T, Ye M, Hu C, Zhou H, Yin Z, Chen Y, Zhang Y, Wang S, Shen J, Thaker H, Jain S, Li Y, Diao Y, Chen Y, Sun X, Fisk MB, Li H. Targeting insulin resistance in type 2 diabetes via immune modulation of cord blood-derived multipotent stem cells (CB-SCs) in stem cell educator therapy: phase I/II clinical trial. BMC Medicine. 2013;11(1). doi: 10.1186/1741-7015-11-160
  29. Gu W, Hu J, Wang W, Li L, Tang W, Sun S, Cui W, Ye L, Zhang Y, Hong J, Zhu D, Ning G. Diabetic ketoacidosis at diagnosis influences complete remission after treatment with hematopoietic stem cell transplantation in adolescents with type 1 diabetes. Diabetes Care. 2012;35(7):1413–1419. doi: 10.2337/dc11-2161
  30. Couri CEB. C-Peptide levels and insulin independence following autologous nonmyeloablative hematopoietic stem cell transplantation in newly diagnosed Type 1 diabetes mellitus. JAMA. 2009;301(15):1573. doi: 10.1001/jama.2009.470
  1. Li, L., Shen, S., Ouyang, J., Hu, Y., Hu, L., Cui, W., Zhang, N., Zhuge, Y., Chen, B., Xu, J., & Zhu, D. (2012). Autologous Hematopoietic Stem Cell Transplantation Modulates Immunocompetent Cells and Improves β-Cell Function in Chinese Patients with New Onset of Type 1 Diabetes. The Journal of Clinical Endocrinology & Metabolism, 97(5), 1729–1736. https://doi.org/10.1210/jc.2011-2188
  2. Araujo DB, Dantas JR, Silva KR, Souto DL, Pereira MFC, Moreira JP, Luiz RR, Claudio-Da-Silva CS, Gabbay MAL, Dib SA, Couri CEB, Maiolino A, Rebelatto CLK, Daga DR, Senegaglia AC, Brofman PRS, Baptista LS, Oliveira JEP, Zajdenverg L, Rodacki M. Allogenic Adipose Tissue-Derived Stromal/Stem Cells and Vitamin D Supplementation in Patients With Recent-Onset Type 1 Diabetes Mellitus: A 3-Month Follow-Up Pilot Study. Front Immunol. 2020 Jun 2;11:993. doi: 10.3389/fimmu.2020.00993. PMID: 32582156; PMCID: PMC7280537.
  3. Lu J, Shen SM, Ling Q, Wang B, Li LR, Zhang W, Qu DD, Bi Y, Zhu DL. One repeated transplantation of allogeneic umbilical cord mesenchymal stromal cells in type 1 diabetes: an open parallel controlled clinical study. Stem Cell Res Ther. 2021 Jun 10;12(1):340. doi: 10.1186/s13287-021-02417-3. PMID: 34112266; PMCID: PMC8194026.
  4. Hu, J., Li, C., Wang, L., Zhang, X., Zhang, M., Gao, H., Yu, X., Wang, F., Zhao, W., Yan, S., & Wang, Y. (2012). Long term effects of the implantation of autologous bone marrow mononuclear cells for type 2 diabetes mellitus. Endocrine Journal, 59(11), 1031–1039. https://doi.org/10.1507/endocrj.ej12-009
  5. Kassem DH, Kamal MM. Therapeutic efficacy of umbilical cord-derived stem cells for diabetes mellitus: a meta-analysis study. Stem Cell Res Ther. 2020 Nov 16;11(1):484. doi: 10.1186/s13287-020-01996-x. PMID: 33198815; PMCID: PMC7667841.
  6. Giannopoulou, E. Z., Puff, R., Beyerlein, A., Von Luettichau, I., Boerschmann, H., Schatz, D., Atkinson, M., Haller, M. J., Egger, D., Burdach, S., & Ziegler, A. (2013). Effect of a single autologous cord blood infusion on beta-cell and immune function in children with new onset type 1 diabetes: a non-randomized, controlled trial. Pediatric Diabetes, 15(2), 100–109. https://doi.org/10.1111/pedi.12072
  7. Snarski, E., Milczarczyk, A., Hałaburda, K., Torosian, T., Paluszewska, M., Urbanowska, E., Król, M., Boguradzki, P., Jedynasty, K., Franek, E., & Wiktor-Jedrzejczak, W. (2015). Immunoablation and autologous hematopoietic stem cell transplantation in the treatment of new-onset type 1 diabetes mellitus: long-term observations. Bone Marrow Transplantation, 51(3), 398–402. https://doi.org/10.1038/bmt.2015.294
  8. Kong, D., Zhuang, X., Wang, D., Qu, H., Jiang, Y., Li, X., Wu, W., Xiao, J., Liu, X., Liu, J., Li, A., Wang, J., Dou, A., Wang, Y., Sun, J., Lv, H., Zhang, G., Zhang, X., Chen, S., … Zheng, C. (2014). Umbilical Cord Mesenchymal Stem Cell Transfusion Ameliorated Hyperglycemia in Patients with Type 2 Diabetes Mellitus. Clinical Laboratory, 60(12/2014). https://doi.org/10.7754/clin.lab.2014.140305
  9. Hu, X. (2013). Early immunotherapy using autologous adult stem cells reversed the effect of anti-pancreatic islets in recently diagnosed type 1 diabetes mellitus: Preliminary results. Medical Science Monitor, 19, 852–857. https://doi.org/10.12659/msm.889525
  10. Jiang, R., Han, Z., Zhuo, G., Qu, X., Li, X., Wang, X., Shao, Y., Yang, S., & Han, Z. C. (2011). Transplantation of placenta-derived mesenchymal stem cells in type 2 diabetes: a pilot study. Frontiers of Medicine, 5(1), 94–100. https://doi.org/10.1007/s11684-011-0116-z
  11. Estrada, E. J., Valacchi, F., Nicora, E., Brieva, S., Esteve, C., Echevarria, L., Froud, T., Bernetti, K., Cayetano, S. M., Velazquez, O., Alejandro, R., & Ricordi, C. (2008). Combined treatment of intrapancreatic autologous bone marrow stem cells and hyperbaric oxygen in type 2 diabetes mellitus. Cell Transplantation, 17(12), 1295–1304. https://doi.org/10.3727/096368908787648119
  12. Snarski, E., Milczarczyk, A., Torosian, T., Paluszewska, M., Urbanowska, E., Król, M., Boguradzki, P., Jedynasty, K., Franek, E., & Wiktor-Jedrzejczak, W. (2010). Independence of exogenous insulin following immunoablation and stem cell reconstitution in newly diagnosed diabetes type I. Bone Marrow Transplantation, 46(4), 562–566. https://doi.org/10.1038/bmt.2010.147
  13. Demour, S. A., Jafar, H., Adwan, S., AlSharif, A., Alhawari, H., Alrabadi, A., Zayed, A., Jaradat, A., & Awidi, A. (2018). Safety and Potential Therapeutic Effect of Two Intracavernous Autologous Bone Marrow Derived Mesenchymal Stem Cells injections in Diabetic Patients with Erectile Dysfunction: An Open Label Phase I Clinical Trial. Urologia Internationalis, 101(3), 358–365. https://doi.org/10.1159/000492120
  14. Zhang, X., Ye, L., Hu, J., Tang, W., Liu, R., Yang, M., Hong, J., Wang, W., Ning, G., & Gu, W. (2012). Acute response of peripheral blood cell to autologous hematopoietic stem cell transplantation in Type 1 diabetic patient. PLoS ONE, 7(2), e31887. https://doi.org/10.1371/journal.pone.0031887
  15. Tong, Q., Duan, L., Xu, Z., Wang, H., Wang, X., Li, Z., Zhang, W., & Zheng, H. (2013). Improved insulin secretion following intrapancreatic UCB transplantation in patients with T2DM. The Journal of Clinical Endocrinology & Metabolism, 98(9), E1501–E1504. https://doi.org/10.1210/jc.2013-1451
  16. Mohamed MT, Embaby EA, Labib A, El-Husseiny M, Khamis H, El-Demery A, Shoukry MM. Effects of exercise in combination with autologous bone marrow stem cell transplantation for patients with type 1 diabetes. Physiother Theory Pract. 2019 Dec;35(12):1233-1242. doi: 10.1080/09593985.2018.1474511. Epub 2018 May 18. PMID: 29775119.
  17. Dantas JR, Araújo DB, Silva KR, Souto DL, de Fátima Carvalho Pereira M, Luiz RR, Dos Santos Mantuano M, Claudio-da-Silva C, Gabbay MAL, Dib SA, Couri CEB, Maiolino A, Rebelatto CLK, Daga DR, Senegaglia AC, Brofman PRS, Baptista LS, de Oliveira JEP, Zajdenverg L, Rodacki M. Adipose tissue-derived stromal/stem cells + cholecalciferol: a pilot study in recent-onset type 1 diabetes patients. Arch Endocrinol Metab. 2021 Nov 3;65(3):342-351. doi: 10.20945/2359-3997000000368. Epub 2021 Apr 29. PMID: 33939911.
  18. Liu Y, Cao DL, Guo LB, Guo SN, Xu JK, Zhuang HF. Amniotic stem cell transplantation therapy for type 1 diabetes: a case report. Journal of international medical research. 2013 Aug;41(4):1370-7.
  19. Bahk JY, Jung JH, Han H, Min SK, Lee YS. Treatment of diabetic impotence with umbilical cord blood stem cell intracavernosal transplant: preliminary report of 7 cases. Exp Clin Transplant. 2010 Jun 1;8(2):150-60.
  20. Mikłosz, A., & Chabowski, A. (2023). Adipose-derived mesenchymal stem cells therapy as a new treatment option for diabetes mellitus. The Journal of Clinical Endocrinology & Metabolism, 108(8), 1889-1897.
  21. Mathur, A., Taurin, S., & Alshammary, S. (2023). The safety and efficacy of mesenchymal stem cells in the treatment of type 2 diabetes-a literature review. Diabetes, Metabolic Syndrome and Obesity, 769-777.
  22. Hogrebe, N. J., Ishahak, M., & Millman, J. R. (2023). Developments in stem cell-derived islet replacement therapy for treating type 1 diabetes. Cell Stem Cell, 30(5), 530-548.
  23. Keymeulen, B., De Groot, K., Jacobs-Tulleneers-Thevissen, D., Thompson, D. M., Bellin, M. D., Kroon, E. J., … & Pipeleers, D. (2024). Encapsulated stem cell–derived β cells exert glucose control in patients with type 1 diabetes. Nature Biotechnology, 42(10), 1507-1514.
  24. Jiao, Y. R., Chen, K. X., Tang, X., Tang, Y. L., Yang, H. L., Yin, Y. L., & Li, C. J. (2024). Exosomes derived from mesenchymal stem cells in diabetes and diabetic complications. Cell Death & Disease, 15(4), 271.
  25. Akter, S., Choubey, M., Mohib, M. M., Arbee, S., Sagor, M. A. T., & Mohiuddin, M. S. (2023). Stem cell therapy in diabetic polyneuropathy: recent advancements and future directions. Brain Sciences, 13(2), 255.
  26. Wang, S., Du, Y., Zhang, B., Meng, G., Liu, Z., Liew, S. Y., … & Shen, Z. (2024). Transplantation of chemically induced pluripotent stem-cell-derived islets under abdominal anterior rectus sheath in a type 1 diabetes patient. Cell, 187(22), 6152-6164.
  27. Reichman, T. W., Ricordi, C., Naji, A., Markmann, J. F., Perkins, B. A., Wijkstrom, M., … & Rickels, M. R. (2023). 836-P: glucose-dependent insulin production and insulin-independence in type 1 diabetes from stem cell–derived, fully differentiated islet cells—Updated data from the VX-880 clinical trial. Diabetes, 72(Supplement_1), 836-P.