Cardiac Conditions Publications

1. Donndorf P, Kundt G, Kaminski A, Yerebakan C, Liebold A, Steinhoff G, Glass A. Intramyocardial bone marrow stem cell transplantation during coronary artery bypass surgery: a meta-analysis. The Journal of thoracic and cardiovascular surgery. 2011 Oct 1;142(4):911-20.
2. Martin-Rendon E, Brunskill SJ, Hyde CJ, Stanworth SJ, Mathur A, Watt SM. Autologous bone marrow stem cells to treat acute mi: a systematic review. European heart journal. 2008 Jun 3;29(15):1807-18.
3. Abdel-Latif A, Bolli R, Tleyjeh IM, Montori VM, Perin EC, Hornung CA, Zuba-Surma EK, Al-Mallah M, Dawn B. Adult bone marrow–derived cells for cardiac repair: a systematic review and meta-analysis. Archives of internal medicine. 2007 May 28;167(10):989-97.
4. Kang S, Yang YJ, Li CJ, Gao RL. Effects of intracoronary autologous bone marrow cells on left ventricular function in acute mi: a systematic review and meta-analysis for randomized controlled trials. Coron Artery Dis. 2008 Aug;19(5):327-35.
5. Reffelmann T, Könemann S, Kloner RA. Promise of blood- and bone marrow-derived stem cell transplantation for functional cardiac repair: putting it in perspective with existing therapy. J Am Coll Cardiol. 2009 Jan 27;53(4):305-8.
6. Lipinski MJ, Biondi-Zoccai GG, Abbate A, Khianey R, Sheiban I, Bartunek J, Vanderheyden M, Kim HS, Kang HJ, Strauer BE, Vetrovec GW. Impact of intracoronary cell therapy on left ventricular function in the setting of acute mi: a collaborative systematic review and meta-analysis of controlled clinical trials. J Am Coll Cardiol. 2007 Oct 30;50(18):1761-7.
7. Rafatian G, Davis DR. Concise Review: The Current State of Stem Cell Therapies for Heart Failure: A Personal Perspective. Stem Cells Transl Med. 2018 Mar;7(3):702-716.
8. Gyöngyösi M, Wojakowski W, Lemarchand P, Lunde K, Tendera M, Bartunek J, Marban E, Assmus B, Henry TD, Traverse JH, Moyé LA, Sürder D, Corti R, Huikuri H, et al. Meta-Analysis of Cell-based CaRdiac stUdiEs (ACCRUE) in Patients with Acute Myocardial Infarction Based on Individual Patient Data. Circ Res. 2015 Aug 28;116(8):1346-1360.
9. Fisher SA, Zhang H, Doree C, Mathur A, Martin-Rendon E. Stem cell treatment for acute myocardial infarction. Cochrane Database Syst Rev. 2015 Sep 30;(9):CD006536.
10. Fisher SA, Doree C, Mathur A, Martin-Rendon E. Stem cell therapy for chronic ischaemic heart disease and congestive heart failure. Cochrane Database Syst Rev. 2016 Dec 24;2016(12):CD007888.
11. Nowbar AN, Mielewczik M, Karavassilis M, Dehbi HM, Shun-Shin MJ, Jones S, Howard JP, Cole GD, Francis DP. Discrepancies in Autologous Bone Marrow Stem Cell Trials and Enhancement of Ejection Fraction (DAMASCENE): weighted regression and meta-analysis. BMJ. 2014 Apr 29;348:g2688.
12. Li Q, Guo Y, Ou Q, Chen N, Wu WJ, Yuan F, O'Brien E, Wang T, Luo L, Hunt GN, Zhu X, Bolli R. Intracoronary administration of cardiac stem cells in mice: a new, improved technique for cell therapy in murine models. Basic Res Cardiol. 2011 Mar;106(2):849-64.
13. Williams AR, Hare JM. Mesenchymal stem cells: biology, pathophysiology, translational findings, and therapeutic implications for cardiac disease. Circ Res. 2011 Sep 30;109(8):923-40.
14. Menasché P. Skeletal myoblasts and cardiac repair. J Mol Cell Cardiol. 2008 Mar;45(4):545-53.
15. Gnecchi M, Zhang Z, Ni A, Dzau VJ. Paracrine mechanisms in adult stem cell signaling and therapy. Circ Res. 2008 Nov 21;103(11):1204-19.
16. Ponemone V, Gupta S, Sundararajan S, et al. Safety and efficacy of bone marrow derived mononuclear cells in acute myocardial infarction patients: Results of a pilot study. Indian Heart J. 2017 Jul-Aug;69(4):457-464.
17. Hu S, Yan G, Xu H, He W, Liu Z, Ma G, Zhang J. Clinical therapy with autologous mesenchymal stem cells for the treatment of patients with idiopathic dilated cardiomyopathy. Intern Med. 2014;53(11):1331-7.
18. Vrtovec B, Poglajen G, Lezaic L, Sever M, Domanovic D, Cernelc P, Socan A, Schrepfer S, Torre-Amione G, Haddad F, Wu JC. Comparison of transendocardial and intracoronary CD34+ cell transplantation in patients with advanced heart failure: results of a randomized, controlled trial. Circ Heart Fail. 2013 Mar 1;6(2):246-53.
19. Vrtovec B, Poglajen G, Sever M, Lezaic L, Domanovic D, Cernelc P, Socan A, Schrepfer S, Torre-Amione G, Haddad F, Wu JC. Effects of intracoronary stem cell transplantation in patients with dilated cardiomyopathy. J Card Fail. 2011 Oct;17(10):272-81.
20. Patel AN, Genovese JA, Allickson JG. Mesenchymal stem cell therapy for cardiovascular disease: clinical applications and biological studies. Am J Cardiovasc Dis. 2011;1(2):89-97.
21. Tse HF, Thambar S, Kwong YL, Rowlings P, Bellamy G, McCrohon J, Thomas P, Bastian B, Chan JK, Lo G, Ho CL, Chan WS, Kwong RY, Parker A, Hauser TH, Chan J, Fong DY, Lau CP. Prospective randomized trial of direct endomyocardial implantation of bone marrow cells for treatment of severe coronary artery diseases (PROTECT-CAD trial). Eur Heart J. 2007 Mar;28(24):2998-3005.
22. Chullikana A, Majumdar AS. Mesenchymal stem cell-based therapy: a new paradigm in regenerative medicine. J Stem Cells. 2010;5(1):23-35.
23. Bolli R, Chugh AR, D'Amario D, Loughran JH, Stoddard MF, Ikram S, Beache GM, Wagner SG, Leri A, Hosoda T, Sanada F, Elmore JB, Goichberg P, Cappetta D, Solankhi NK, Fahsah I, Rokosh DG, Slaughter MS, Kajstura J, Anversa P. Cardiac stem cells in patients with ischaemic cardiomyopathy (SCIPIO): initial results of a randomised phase 1 trial. Lancet. 2011 Nov 26;378(9806):1847-57.
24. Harvey A, Fertig E, Edelman E, Iafrati M, Hegde S. Clinical use of stem cells in cardiovascular medicine. Methodist Debakey Cardiovasc J. 2012 Jan-Mar;8(1):36-43.
25. Tendera M, Wojakowski W, Ruzyllo W, Chojnowska L, Kepka C, Tracz W, Musialek P, Piwowarska J, Nessler J, Buszman P, Grajek S, Breborowicz P, Majka M, Ratajczak MZ, Penn M, Janiszewski M, Zaruba M, et al. Intracoronary infusion of bone marrow-derived selected CD34+CXCR4+ cells and non-selected mononuclear cells in patients with acute STEMI and reduced left ventricular ejection fraction: results of randomized, multicentre Myocardial Regeneration by Intracoronary Infusion of Selected Population of Stem Cells in Acute Myocardial Infarction (REGENT) trial. Eur Heart J. 2009 May;30(11):1313-21.
26. Simari RD, Moyé LA, Skarlatos SI, Ellis SG, Zhao DX. Stem Cell Therapy for Cardiac Disease: Summarizing the Evidence. Methodist Debakey Cardiovasc J. 2013 Apr-Jun;9(2):80-7.
27. Vrtovec B, Poglajen G, Lezaic L, Sever M, Domanovic D, Cernelc P, Socan A, Schrepfer S, Torre-Amione G, Haddad F, Wu JC. Stem cell transplantation in patients with heart failure. Cell Transplant. 2011;20(10):1317-24.
28. Mohsin S, Siddiqi S, Collins B, Sussman MA. Empowering Adult Stem Cells for Myocardial Regeneration. Circ Res. 2011 Sep 30;109(8):1415-28.
29. Laflamme MA, Murry CE. Regenerating the heart. Nat Biotechnol. 2005 Jul;23(7):845-56.
30. Yang ZJ, Ma DC, Wang W, Xu SL, Zhang YQ, Chen B, Li DX, Sun YL, Xu ZY, Xu YW. Experimental study of bone marrow mononuclear cells transplanted into swine hearts after acute myocardial infarction. J Zhejiang Univ Sci B. 2005 Oct;6(10):877-82.
31. Orlic D, Kajstura J, Chimenti S, Jakoniuk I, Anderson SM, Li B, Pickel J, McKay R, Nadal-Ginard B, Bodine DM, Leri A, Anversa P. Bone marrow cells regenerate infarcted myocardium. Nature. 2001 Apr 5;410(6829):701-5.
32. Kocher AA, Schuster MD, Szabolcs MJ, Takuma S, Burkhoff D, Wang J, Homma S, Edwards NM, Itescu S. Neovascularization of ischemic myocardium by human bone-marrow-derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function. Nat Med. 2001 Apr;7(4):430-6.

33. Fazel S, Cimini M, Chen L, Li S, Angoulvant D, Fedak P, Verma S, Weisel RD, Keating A, Li RK. Cardioprotective c-kit+ cells are from the bone marrow and regulate the myocardial balance of angiogenic cytokines. J Clin Invest. 2006 Jul;116(7):1865-77.
34. Nygren JM, Jovinge S, Breitbach M, Säwén P, Röll W, Hescheler J, Taneera J, Fleischmann BK, Jacobsen SE. Bone marrow-derived hematopoietic cells generate cardiomyocytes at a low frequency through cell fusion, but not transdifferentiation. Nat Med. 2004 May;10(5):494-501.
35. Murry CE, Soonpaa MH, Reinecke H, Nakajima H, Nakajima HO, Rubart M, Pasumarthi KB, Virag JI, Bartelmez SH, Poppa V, Bradford G, Dowell JD, Williams DA, Field LJ. Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts. Nature. 2004 Apr 22;428(6983):664-8.
36. Oh H, Bradfute SB, Gallardo TD, Nakamura T, Gaussin V, Mishina Y, Pocius J, Michael LH, Behringer RR, Garry DJ, Entman ML, Schneider MD. Cardiac progenitor cells from adult myocardium: homing, differentiation, and fusion after infarction. Proc Natl Acad Sci U S A. 2003 Jul 22;100(21):12313-8.
37. Beltrami AP, Barlucchi L, Torella D, Baker M, Limana F, Chimenti S, Kasahara H, Rota M, Musso E, Urbanek K, Leri A, Kajstura J, Nadal-Ginard B, Anversa P. Adult cardiac stem cells are multipotent and support myocardial regeneration. Cell. 2003 Sep 19;114(6):763-76.
38. Makino S, Fukuda K, Miyoshi S, Konishi F, Kodama H, Pan J, Sano M, Takahashi T, Hori S, Abe H, Hata J, Umezawa A, Ogawa S. Cardiomyocytes can be generated from marrow stromal cells in vitro. J Clin Invest. 1999 Sep;103(5):697-705.
39. Badorff C, Brandes RP, Popp R, Rupp S, Urbich C, Aicher A, Fleming I, Busse R, Zeiher AM, Dimmeler S. Transdifferentiation of blood-derived human adult endothelial progenitor cells into functionally active cardiomyocytes. Circulation. 2003 Jul 8;107(25):1024-32.
40. Toma C, Pittenger MF, Cahill KS, Byrne BJ, Kessler PD. Human mesenchymal stem cells differentiate to a cardiomyocyte phenotype in the adult murine heart. Circulation. 2002 Jan 14;105(1):93-8.
41. Barile L, Messina E, Giacomello A, Marbán E. Endogenous cardiac stem cells. Prog Cardiovasc Dis. 2007 Jul-Aug;50(1):31-48.
42. Barbash IM, Chouraqui P, Baron J, Feinberg MS, Etzion S, Tessone A, Miller L, Guetta E, Zipori D, Kedes LH, Kloner RA, Leor J. Systemic delivery of bone marrow–derived mesenchymal stem cells to the infarcted myocardium: feasibility, cell migration, and body distribution. Circulation. 2003 Aug 26;108(7):863-8.
43. Shake JG, Gruber PJ, Baumgartner WA, Senechal G, Meyers J, Redmond JM, Pittenger MF, Martin BJ. Mesenchymal stem cell implantation in a swine myocardial infarction model: engraftment and functional effects. Ann Thorac Surg. 2002 Jun;73(6):1919-25.
44. Amado LC, Saliaris AP, Schuleri KH, St John M, Xie JS, Cattaneo S, Durand DJ, Fitton T, Kuang JQ, Stewart G, Lehrke S, Baumgartner WW, Martin BJ, Heldman AW, Hare JM. Cardiac repair with intramyocardial injection of allogeneic mesenchymal stem cells after myocardial infarction. Proc Natl Acad Sci U S A. 2005 Feb 22;102(32):11474-9.
45. Behfar A, Terzic A. Stem cells and cardiovascular repair. Mayo Clin Proc. 2006 Jun;81(6):834-40.
46. Mangi AA, Noiseux N, Kong D, He H, Rezvani M, Ingwall JS, Dzau VJ. Mesenchymal stem cells modified with Akt prevent remodeling and restore performance of infarcted hearts. Nat Med. 2003 Sep;9(9):1195-201.
47. Gnecchi M, He H, Liang OD, Melo LG, Morello F, Mu H, Noiseux N, Zhang L, Pratt RE, Ingwall JS, Dzau VJ. Paracrine action accounts for marked protection of ischemic heart by Akt-modified mesenchymal stem cells. Nat Med. 2005 Apr;11(4):367-8.
48. Tse HF, Kwong YL, Chan JK, Lo G, Ho CL, Lau CP. Angiogenesis in ischaemic myocardium by intramyocardial autologous bone marrow mononuclear cell implantation. Lancet. 2003 Jul 19;362(9377):545-6.
49. Stamm C, Westphal B, Kleine HD, Petzsch M, Kittner C, Klinge H, Schümichen C, Nienaber CA, Freund M, Steinhoff G. Autologous bone-marrow stem-cell transplantation for myocardial regeneration. Lancet. 2003 Jan 4;361(9351):45-6.
50. Assmus B, Schächinger V, Teupe C, Britten M, Lehmann R, Döbert N, Grünwald F, Aicher A, Urbich C, Martin H, Hoelzer D, Dimmeler S, Zeiher AM. Transplantation of Progenitor Cells and Regeneration Enhancement in Acute Myocardial Infarction (TOPCARE-AMI). Circulation. 2002 Dec 3;106(24):3009-17.
51. Strauer BE, Brehm M, Zeus T, Köstering M, Hernandez A, Sorg RV, Kögler G, Wernet P. Repair of infarcted myocardium by autologous intracoronary mononuclear bone marrow cell transplantation in humans. Circulation. 2002 Dec 10;106(15):1913-8.
52. Hamano K, Nishida M, Hirata K, Mikamo A, Li TS, Harada M, Miura T, Matsuzaki M. Local implantation of autologous bone marrow cells for therapeutic angiogenesis in patients with ischemic heart disease: clinical trial and preliminary results. Jpn Circ J. 2001 Nov;65(11):845-7.
53. Perin EC, Dohmann HF, Borojevic R, Silva SA, Sousa AL, Mesquita CT, Rossi MI, Carvalho AC, Dutra HS, Dohmann HJ, Silva GV, Belém L, Vivacqua R, Rangel FO, et al. Transendocardial, autologous bone marrow cell transplantation for severe, chronic ischemic heart failure. Circulation. 2003 May 27;107(18):2294-302.
54. Herreros J, Prósper F, Pérez A, Gavira JJ, García-Velloso MJ, Barba J, Sánchez PL, Cañizo MC, Martín-Luengo C, Alegría E, López-Holgado N, González-Santos JM, Martín J, et al. Autologous intramyocardial injection of cultured skeletal muscle-derived stem cells in patients with non-acute myocardial infarction. Eur Heart J. 2003 Oct;24(22):2012-20.
55. Menard C, Hagège AA, Agbulut O, Barro M, Morichetti MC, Brasselet C, Bel A, Messas E, Bissery A, Bruneval P, Desnos M, Puceat M, Menasché P. Transplantation of cardiac-committed mouse embryonic stem cells to infarcted sheep myocardium: a preclinical study. Lancet. 2005 Oct 1;366(9490):1005-12.
56. Menasché P, Hagege AA, Scorsin M, Pouzet B, Desnos M, Duboc D, Schwartz K, Vilquin JT, Marolleau JP. Myoblast transplantation for heart failure. Lancet. 2001 May 12;357(9252):279-80.
57. Menasché P. Skeletal myoblast transplantation for cardiac repair: problems and prospects. J Mol Cell Cardiol. 2003 Nov;35(11):1153-60.
58. Smits PC, van Geuns RJ, Poldermans D, Bountioukos M, Onderwater EE, Lee CH, Maat AP, Serruys PW. Catheter-based intramyocardial injection of autologous skeletal myoblasts as a primary treatment of ischemic heart failure: clinical experience with six-month follow-up. J Am Coll Cardiol. 2003 Nov 5;42(9):2063-9.
59. Pagani FD, DerSimonian H, Zawadzka A, Wetzel K, Edge AS, Jacoby DB, Dinsmore JH, Wright S, Aretz TH, Eisen HJ, Aaronson KD. Autologous skeletal myoblasts transplanted to ischemia-damaged myocardium in humans: histological analysis of cell survival and differentiation. J Am Coll Cardiol. 2003 Sep 3;41(11):879-88.
60. Siminiak T, Kalawski R, Fiszer D, Jerzykowska O, Rzeźniczak J, Kalmucki P, Kurpisz M. Autologous skeletal myoblast transplantation for the treatment of postinfarction myocardial injury: phase I clinical study with 12 months of follow-up. Am Heart J. 2004 Oct;148(4):531-7.
61. Menasché P. Cell therapy trials for heart regeneration — lessons learned and future directions. Nat Rev Cardiol. 2018 Nov;15(11):659-671.
62. Menard C, Hagege AA, Desnos M, Puceat M, Menasché P. Current state of the art of myocardial regeneration. Curr Opin Organ Transplant. 2006 Oct;11(5):473-80.
63. Boyle AJ, Schulman SP, Hare JM, Oettgen P. Is stem cell therapy ready for patients? Stem Cell Therapy for Cardiac Repair. Circulation. 2006 Feb 21;113(7):1278-89.
64. Karantalis V, Schulman IH, Balkan W, Hare JM. Allogeneic cell therapy: a new paradigm in therapeutics. Circ Res. 2015 Apr 24;116(8):1513-26.
65. Sanganalmath SK, Bolli R. Cell therapy for heart failure: a comprehensive overview of experimental and clinical studies, current challenges, and future directions. Circ Res. 2013 Aug 30;113(6):810-34.
66. Williams AR, Hare JM. Stem cell therapy for the heart: hype or hope? Nat Rev Cardiol. 2011 Jun;8(6):329-40.
67. Behfar A, Crespo-Diaz R, Terzic A, Gersh BJ. Cell therapy for cardiac repair — lessons from clinical trials. Nat Rev Cardiol. 2014 Dec;11(12):709-20.
68. van Laake LW, Passier R, Doevendans PA, Mummery CL. Human embryonic stem cell-derived cardiomyocytes and cardiac repair in rodents. Circ Res. 2008 Sep 12;102(9):1008-10.
69. Laflamme MA, Chen KY, Naumova AV, Muskheli V, Fugate JA, Dupras SK, Reinecke H, Xu C, Hassanipour M, Police S, O'Sullivan C, Collins L, Chen Y, Minami E, Gill EA, Ueno S, Yuan C, Gold J, Murry CE. Cardiomyocytes derived from human embryonic stem cells in pro-survival factors enhance function of infarcted rat hearts. Nat Biotechnol. 2007 Sep;25(9):1015-24.
70. Yang L, Soonpaa MH, Adler ED, Roepke TK, Kattman SJ, Kennedy M, Henckaerts E, Bonham K, Abbott GW, Linden RM, Field LJ, Keller GM. Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population. Nature. 2008 May 1;453(7194):524-8.

71. Laflamme MA, Chen KY, Naumova AV, Muskheli V, Fugate JA, Dupras SK, Reinecke H, Xu C, Hassanipour M, Police S, O'Sullivan C, Collins L, Chen Y, Minami E, Gill EA, Ueno S, Yuan C, Gold J, Murry CE. Cardiomyocytes derived from human embryonic stem cells in pro-survival factors enhance function of infarcted rat hearts. Nat Biotechnol. 2007 Sep;25(9):1015-24.
72. Yang L, Soonpaa MH, Adler ED, Roepke TK, Kattman SJ, Kennedy M, Henckaerts E, Bonham K, Abbott GW, Linden RM, Field LJ, Keller GM. Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population. Nature. 2008 May 1;453(7194):524-8.
73. Shiba Y, Fernandes S, Zhu WZ, Filice D, Muskheli V, Kim J, Palpant NJ, Gantz J, Moyes KW, Reinecke H, Van Biber B, Dardas T, Mignone JL, Izawa A, Hanna R, Viswanathan M, Gold JD, Kotlikoff MI, Sarvazyan N, Kay MW, Murry CE, Laflamme MA. Human ES-cell-derived cardiomyocytes electrically couple and suppress arrhythmias in injured hearts. Nature. 2012 May 10;489(7415):322-5.
74. Robey TE, Saiget MK, Reinecke H, Murry CE. Systems approaches to preventing transplanted cell death in cardiac repair. J Mol Cell Cardiol. 2008 May;45(4):567-81.
75. Ye L, Chang YH, Xiong Q, Zhang P, Zhang L, Somasundaram P, Lepley M, Swingen C, Su L, Wendel JS, Guo J, Jang A, Rosenbush D, Greder L, Dutton JR, Zhang J. Cardiac repair in a porcine model of acute myocardial infarction with human induced pluripotent stem cell–derived cardiovascular cells. Cell Stem Cell. 2014 Dec 4;15(6):750-61.
76. Shiba Y, Gomibuchi T, Seto T, Wada Y, Ichimura H, Tanaka Y, Ogasawara T, Okada K, Shiba N, Sakamoto K, Ido D, Shiina T, Ohkura M, Nakajima K, et al. Allogeneic transplantation of iPS cell–derived cardiomyocytes regenerates primate hearts. Nature. 2016 Oct 20;538(7625):388-391.
77. Jiang Y, Jahagirdar BN, Reinhardt RL, Schwartz RE, Keene CD, Ortiz-Gonzalez XR, Reyes M, Lenvik T, Lund T, Blackstad M, Du J, Aldrich S, Lisberg A, Low WC, Largaespada DA, Verfaillie CM. Pluripotency of mesenchymal stem cells derived from adult marrow. Nature. 2002 Jul 4;418(6893):41-49.
78. Psaltis PJ, Zannettino AC, Worthley SG, Gronthos S. Concise Review: Mesenchymal Stromal Cells: Potential for Cardiovascular Repair. Stem Cells. 2008 Sep;26(9):2201-2210.
79. Quevedo HC, Hatzistergos KE, Oskouei BN, Feigenbaum GS, Rodriguez JE, Valdes D, Pattany PM, Zambrano JP, Hu Q, McNiece I, Heldman AW, Hare JM. Allogeneic mesenchymal stem cells restore cardiac function in chronic ischemic cardiomyopathy via trilineage differentiating capacity. Proc Natl Acad Sci U S A. 2009 Jun 16;106(33):14022-14027.
80. Hare JM, Traverse JH, Henry TD, Dib N, Strumpf RK, Schulman SP, Gerstenblith G, DeMaria AN, Denktas AE, Gammon RS, Hermiller JB Jr, Reisman MA, Schaer GL, Sherman W. A randomized, double-blind, placebo-controlled, dose-escalation study of intravenous adult human mesenchymal stem cells (Prochymal) after acute myocardial infarction. J Am Coll Cardiol. 2009 Dec 8;54(24):2277-86.
81. Hare JM, Fishman JE, Gerstenblith G, DiFede Velazquez DL, Zambrano JP, Suncion VY, Tracy M, Ghersin E, Johnston PV, Brinker JA, Breton E, Davis-Sproul J, Schulman IH, Byrnes J, et al. Comparison of allogeneic vs autologous bone marrow–derived mesenchymal stem cells delivered by transendocardial injection in patients with ischemic cardiomyopathy: the POSEIDON randomized trial. JAMA. 2012 Dec 12;308(22):2369-79.
82. Mathiasen AB, Qayyum AA, Jørgensen E, Helqvist S, Fischer-Nielsen A, Kofoed KF, Haack-Sørensen M, Ekblond A, Kastrup J. Bone marrow–derived mesenchymal stromal cell treatment in patients with severe ischemic heart failure: a randomized placebo-controlled trial (MSC-HF trial). Eur Heart J. 2015 Jun 7;36(27):1744-53.
83. Karuppanan S, Azizi SA. Stem cell therapy for cardiac regeneration: the challenges and promises. Ann Transl Med. 2017 Jul;5(14):289.
84. Hatzistergos KE, Quevedo H, Oskouei BN, Hu Q, Feigenbaum GS, Margitich IS, Mazhari R, Boyle AJ, Zambrano JP, Rodriguez JE, Dulce R, Pattany PM, Valdes D, Revilla C, Heldman AW, McNiece I, Hare JM. Bone marrow mesenchymal stem cells stimulate cardiac stem cell proliferation and differentiation. Circ Res. 2010 Jan 8;107(7):913-922.
85. Ibrahim AG, Cheng K, Marbán E. Exosomes as critical agents of cardiac regeneration triggered by cell therapy. Stem Cell Reports. 2014 Sep 9;2(5):606-619.
86. Lai RC, Arslan F, Lee MM, Sze NS, Choo A, Chen TS, Salto-Tellez M, Timmers L, Lee CN, El Oakley RM, Pasterkamp G, de Kleijn DP, Lim SK. Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury. Stem Cell Res. 2010 May;4(3):214-222.
87. Barile L, Lionetti V, Cervio E, Matteucci M, Gherghiceanu M, Popescu LM, Torre T, Siclari F, Moccetti T, Vassalli G. Extracellular vesicles from human cardiac progenitor cells inhibit cardiomyocyte apoptosis and improve cardiac function after myocardial infarction. Cardiovasc Res. 2014 Apr 1;103(4):530-541.
88. Ibrahim AG, Cheng K, Malliaras K, Zhang Y, Sun B, Matsushita N, Smith RR, Marbán E. Cardiosphere-derived cells secreted exosomes modulate immune responses in the infarcted heart. J Am Coll Cardiol. 2014 Sep 23;63(11):1428-1438.
89. Gallet R, Dawkins J, Valle J, Simsolo E, de Couto G, Middleton R, Tseliou E, Luthringer D, Kreke M, Smith RR, Marbán L, Ghaleh B, Marbán E. Exosomes secreted by cardiosphere-derived cells reduce scarring, attenuate adverse remodelling, and improve function in chronic myocardial infarction. J Am Coll Cardiol. 2017 Apr 11;69(14):1813-1823.
90. Barile L, Moccetti T, Marbán E, Vassalli G. Roles of exosomes in cardioprotection. Eur Heart J. 2017 Apr 7;38(18):1372-1379.
91. Li TS, Cheng K, Malliaras K, Smith RR, Zhang Y, Sun B, Matsushita N, Blusztajn A, Terrovitis J, Kusuoka H, Marbán E. Direct comparison of different stem cell types and subpopulations reveals superior paracrine potency and myocardial repair efficacy with cardiosphere-derived cells. J Am Coll Cardiol. 2012 May 15;59(20):942-953.
92. Gallet R, Tseliou E, Dawkins JF, Middleton RC, Valle J, Ye L, Roe ND, Zawadzka A, Hatzistergos KE, Sampaio LC, Klingemann H, de Couto G, et al. Intracoronary delivery of allogeneic cardiosphere-derived cells at the time of reperfusion in myocardial infarction: the ALLSTAR trial. Eur Heart J. 2017 Jul 21;38(23):2017-2026.
93. Chong JJH, Yang X, Don CW, Minami E, Liu YW, Weyers JJ, Mahoney WM Jr, Van Biber B, Cook SM, Palpant NJ, Gantz JA, Fugate JA, Muskheli V, Gough GM, Vogel KW, Astley CA, Hotchkiss CE, Baldessari A, Pabon L, Reinecke H, Gill EA, Nelson V, Kiem HP, Laflamme MA, Murry CE. Human embryonic-stem-cell–derived cardiomyocytes regenerate non-human primate hearts. Nature. 2014 Nov 6;510(7504):273-277.
94. Guzzo RM, Gibson MS, Xu RH, Lee AS. The role of stem cells in the treatment of heart failure. Curr Opin Organ Transplant. 2014 Oct;19(5):517-522.
95. Bolli R, Ghafghazi S. Stem cells: cell therapy for cardiac repair: what is needed to move forward? Nat Rev Cardiol. 2017 Sep;14(9):492-493.
96. Pochampally RR. Concise Review: Therapeutic Potential of Extracellular Vesicles Derived from Mesenchymal Stem Cells. Stem Cells Transl Med. 2015 Dec;4(12):1359-1365.
97. van der Spoel TI, Jansen of Lorkeers SJ, Agostoni P, van Belle E, Gyöngyösi M, Sluijter JP, Cramer MJ, Doevendans PA, Chamuleau SA. Human relevance of pre-clinical studies in stem cell therapy: systematic review and meta-analysis of large animal models of ischaemic heart disease. Cardiovasc Res. 2011 Jun 1;91(4):649-658.
98. Chong JJ, Forte E, Harvey RP. Developmental origins and lineage descendants of endogenous cardiac stem cells. Stem Cell Res. 2014 Jan;13(3):592-614.
99. Banerjee MN, Bolli R, Hare JM. Clinical Studies of Cell Therapy in Cardiovascular Medicine: Recent Developments and Future Directions. Circ Res. 2018 Apr 13;122(7):767-781.
100. Chong JJH, Murry CE. Cardiac regeneration using pluripotent stem cells — Progression to large animal models. Stem Cell Res. 2014 Jan;13(3 Pt B):654-665.